Her career received a setback in 2002 and 2003, all her movies, Mujhse Dosti Karoge!, Jeena Sirf Merre Liye, Talaash: The Hunt Begins…, Khushi, Main Prem Ki Diwani Hoon, LOC Kargil, were quite unsuccessful at the box-office. Her movies released in 2004 and 2005, Chameli, Yuva, Fida, Aitraaz, Dev, Hulchal, Bewafaa, Dosti: Friends Forever received a lukewarm response at the box-office. However, her roles in Chameli and Dev were critically acclaimed. In 2006, she starred in 36 China Town, Chup Chup Ke, Omkara and did a cameo appearance in Don – The Chase Begins Again. Her portrayal of Dolly (based on Desdemona, from the Shakespearean play, Othello) received rave critical reviews.
Don and his gang, consisting of Anita (Eesha Koppikhar) his girlfriend and Narang (Pawan Malhotra) travel to India to trade some drugs. D'Silva and his team follow them there - Don is injured fatally during a police chase. D'Silva keeps this a secret - he decides to track down a look alike of Don named Vijay (also Shahrukh Khan) and asks him to pose as Don so that he (D'Silva) can get the gang arrested. Vijay agrees when D'Silva promises to admit Deepu (Tanay Chheda), a child Vijay looks after, to a good school. Meanwhile, Jasjit (Arjun Rampal), Deepu's real father has just been released from prison and becomes bent on killing D'Silva. This is because Jasjit was committing a crime in order to save Deepu and his wife from a gang of criminals and D'Silva had Jasjit arrested, thereby preventing Jasjit from saving his wife from death.
Vijay is admitted to the same hospital as Don, who is in a coma. Vijay, through an operation, soon gets all the scars which Don has, put on his body. Suddenly, Don dies of heart failure. When Vijay (as Don) re-enters the gang, he will have lost his memory - the more he learns about Don, the more he shall remember. The gang have a disc which contains some of their most vital information. Vijay agrees to take this disc to D'Silva - Roma decides to go with him. When they arrive, Roma attempts to kill Vijay (thinking he is Don). However, D'Silva arrives and tells Roma about his and Vijay's plan. Roma and Vijay now find themselves falling in love. D'Silva soon finds Singhania and kills him. In a police raid, Vijay and the gang members are all arrested by Malik and his team. D'Silva is killed in a blast - this is unfortunate for Vijay because D'Silva is the only person who could prove that Vijay is not the real Don. Vijay escapes and tries to pursue the disc he gave to D'Silva in order to prove his innocence.
Jasjit still continues to try and find his son, Deepu. It is revealed he is in possession of the disc - he receives a telephone call saying that if he wants to see his son again, he will have to bring the disc to the men who have Deepu hostage. At this meeting, it is revealed that D'Silva has been alive all along and is actually Vardhan, the longtime rival of Singhania. Jasjit manages to escape with his son. He meets Vijay and Roma and reveals that D'Silva is really Vardhan - the three hatch a plot to help Malik arrest Vardhan. The next day, Jasjit arranges a meeting with Vardhan, saying he will hand over the disc. Vardhan and Vijay engage in a fight until Vardhan is defeated and arrested. Vijay gets badly injured during the fight, and is rushed to hospital - before he leaves, Roma confesses her love for him. In a final twist, it is revealed that the real Don is alive and was pretending to be Vijay the whole time. In the hospital, Don quickly recovered from the coma and overheard D'Silva's conversation with Vijay. He switched places with Vijay, meaning Vijay died of heart failure. It is also revealed that the disc Don gave to the police was fake. In the end, Don and Anita both escape, knowing the police nor Roma will ever capture Don.^ "Don - The Chase Begin Again". Retrieved 26 December 2010.
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^ IndiaFM News Bureau (2006-12-22). "Don flies to Berlin Film Festival".
^ "'King of Don 2 is SRK'". Sify.com. Retrieved 2012-07-16.
^ "Akshay turns down the remake of ‘Don’ : Bollywood News". ApunKaChoice.Com. 2005-06-07. Retrieved 2011-06-30.
^ "Priyanka training in martial arts | Bollywood News | Hindi Movies News | News". BollywoodHungama.com. 2006-11-02. Retrieved 2012-07-16.
^ "Don music launch amongst 30000 people". Bollywoodhungama.com. 2006-08-23. Retrieved 2011-06-24.
^ "Box Office 2006". Boxofficeindia.com accessdate= 2011-08-24.
^ "Top Lifetime Grossers OVERSEAS". Boxofficeindia.com. Retrieved 2011-09-21.
^ "Top Lifetime Grossers Worldwide". Boxofficeindia.com. Retrieved 26 December 2010.
^ Shekhar, Mayank (21 October 2006). "Cuts to the chase". Mumbai Mirror. Retrieved 2011-07-26.
^ Kazmi, Nikhat (21 October 2006). "Don". The Times of India. Retrieved 2011-07-26.
^ Mohamed, Khalid (20 October 2006). "Don? Don’t". Daily News and Analysis. Retrieved 2011-07-26.
^ Adarsh, Taran (20 October 2006). "Don - The Chase Begins Again : Movie Review". Bollywood Hungama. Retrieved 2011-07-26.
^ Elley, Derek (3 January 2007). "Don". Variety.
^ "All Time 100 cr Grossers Of Bollywood". Boxofficecapsule.com. Retrieved 2012-07-16.Reviews for Don were generally mixed. Mumbai Mirror's Mayank Shekhar gave it a rating of 4 out of 5, criticizing the treatment of certain scenes in comparison to the original, and questioning the need for the remake, saying "As adequate and astounding an echo it may be, Akhtar's film can at best hope to share its space, a rack or two lower in history, to an original voice. Let this be an ample aberration, and not a norm. We usually pay to watch films we haven't seen." Nikhat Kazmi of The Times of India did not like a few casting choices. Khalid Mohammed of the Daily News and Analysis rated it 2 on a scale of 5. Bollywood Hungama's Taran Adarsh gave it 3 out of 5. Variety stated that the film "could have been much better."Don is extremely dangerous - he has even been known to kill one of his own men Ramesh, who attempted to leave Don and his gang without informing Don first. Ramesh's fiance Kamini (Kareena Kapoor) decides to help D'Silva arrest Don but in the process, she is also killed by Don. Now, Ramesh's sister Roma (Priyanka Chopra) manages to get her way into Don's gang by persuading them that she is wanted by the police - her real plan is to murder Don in order to avenge her brother and his fiance.